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KMID : 1037820140030010005
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Journal of Pain and Autonomic Disorders
2014 Volume.3 No. 1 p.5 ~ p.13
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Pharmacological Management of Chronic Non-Cancer Pain
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Lee Dong-Kuck
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Abstract
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Chronic non-cancer pain is a pervasive health issue that exerts a substantial social and economic burden on both the affected individual and society. Mechanisms underlying chronic pain include a complex interaction of physiological, emotional, cognitive, social, and environmental factors. To manage chronic pain, a multimodal approach is needed to address pain and reduce suffering, depression, anxiety, anger and other cognitive changes. In recent years, various adjunct analgesics have been used to treat chronic pain syndromes, including NSAIDs, antidepressants, anticonvulsants, local anesthetics, topical agents, baclofen, and N-methyl-D-aspartate receptor antagonists. Tricyclic antidepressants and anticonvulsants have been used as the first-line drugs in the treatment of neuropathic pain. If a patient does not respond to treatment with different agents within one drug class, agents from a second drug class may be added. When all first-line
options have been exhausted, narcotic analgesics may provide some benefit, with the risks of tolerance and addiction.
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KEYWORD
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Chronic non-cancer pain, Pharmacological management
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